Philippe F.Y Vincent, Ph.D.
Dr. Vincent earned his Ph.D. in Cell Biology and Animal Physiopathology in 2015 from the University of Bordeaux. He joined Johns Hopkins in 2016, where he focuses on understanding how sound is encoded by IHC ribbon synapses and developing strategies to promote synapse and hair cell regeneration. In 2024, Dr. Vincent was promoted to Assistant Professor in the Department of Otolaryngology–Head and Neck Surgery at Johns Hopkins University.
Dr. Vincent describes himself as a passionate auditory neuroscientist and electrophysiologist.
When Dr. Vincent is not behind his patch-clamp rig, he enjoys spending time with his wife and two children. Outside the lab, he also enjoys baking, gardening, and playing video games.
Fun Fact: “I did not intend to work in Auditory Neuroscience at first.”
Dr. Vincent’s office is located on the 8th floor of Ross Building (Ross 818), 720 Rutland Ave, Baltimore, MD 21205.
The sound signal is encoded by ribbon synapses between Inner Hair Cells and type-I Auditory Nerve Fibers in the cochlea. Ribbon synapses are characterized by highly specialized properties. They are fast, reliable, and indefatigable, making them distinct from conventional synapses found in the central nervous system.
The Vincent lab seeks to understand how the mammalian auditory system transforms sound into precise neural signals, with a particular focus on the molecular mechanisms that shape auditory nerve fiber activity. Using advanced electrophysiological, optogenetic, imaging, and molecular approaches, the Vincent lab investigates how synaptic transmission operates between IHCs and Type-I ANF to encode acoustic information. We are particularly interested in the role of the lateral olivocochlear efferent system, which originates from the lateral superior olive in the brainstem, and how it sets the distinct encoding properties of the auditory nerve fibers. By linking molecular mechanisms to neuronal function, our goal is to understand how efferent signaling helps to encode sensory input into patterns of auditory nerve activity that the brain can understand. In addition, by uncovering these mechanisms, we aim at understanding how the LOC efferent system may protect ribbon synapses from noise damage.
A second major focus of our research is the development of strategies to restore auditory function following sensory hair cell loss or damage to ribbon synapses. We investigate how supporting cells can be reprogrammed into new hair cells and whether these regenerated cells can establish functional synaptic connections with auditory nerve fibers. Combining regenerative biology with electrophysiology, optogenetics, and confocal imaging, we aim to determine not only whether new hair cells can be generated, but whether they can reproduce the highly specialized synaptic and coding properties required for hearing. Ultimately, my research program seeks to bridge fundamental discoveries in auditory neuroscience with innovative therapeutic strategies for restoring hearing.